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bebop
poly
Go2020–2023
bebop / poly

poly

A Go package for engineering organisms.

6Distinct people
17Mentions
0Explicit recommenders
738GitHub stars
REPOSITORY AT A GLANCE

What to know before exploring

What it is

A Go package for engineering organisms.

GitHub

Where it is used

No documented product use has been verified yet.

What people are saying

No recommendation phrase was found in the indexed comments.

No classified warning is attached to this page. Read the discussions before treating silence as approval.

Also in these discussions

Mentioned in the same Hacker News threads. That is not proof they are substitutes.

This week on Hacker News

Nov 7–Nov 14 UTC · Direct repository links and separately labeled related project stories. Indexed through 11/14/2026, 12:54:37 PM UTC.

No direct repository links were found in the indexed HN discussions over the past seven days. Older discussions are available below.

Mentions over time

HN mentions by month17 dated mentions

Observed mentions: 2020-10-16 17:59:47 UTC to 2023-04-13 12:50:03 UTC.

01232020-10-01 00:00:00 UTC to 2020-11-01 00:00:00 UTC (exclusive): 1 mentions; 0 submissions, 1 commentsOct 20202020-11-01 00:00:00 UTC to 2020-12-01 00:00:00 UTC (exclusive): 0 mentions; 0 submissions, 0 comments2020-12-01 00:00:00 UTC to 2021-01-01 00:00:00 UTC (exclusive): 0 mentions; 0 submissions, 0 comments2021-01-01 00:00:00 UTC to 2021-02-01 00:00:00 UTC (exclusive): 1 mentions; 0 submissions, 1 comments2021-02-01 00:00:00 UTC to 2021-03-01 00:00:00 UTC (exclusive): 0 mentions; 0 submissions, 0 comments2021-03-01 00:00:00 UTC to 2021-04-01 00:00:00 UTC (exclusive): 0 mentions; 0 submissions, 0 comments2021-04-01 00:00:00 UTC to 2021-05-01 00:00:00 UTC (exclusive): 0 mentions; 0 submissions, 0 comments2021-05-01 00:00:00 UTC to 2021-06-01 00:00:00 UTC (exclusive): 0 mentions; 0 submissions, 0 comments2021-06-01 00:00:00 UTC to 2021-07-01 00:00:00 UTC (exclusive): 1 mentions; 0 submissions, 1 comments2021-07-01 00:00:00 UTC to 2021-08-01 00:00:00 UTC (exclusive): 0 mentions; 0 submissions, 0 comments2021-08-01 00:00:00 UTC to 2021-09-01 00:00:00 UTC (exclusive): 0 mentions; 0 submissions, 0 comments2021-09-01 00:00:00 UTC to 2021-10-01 00:00:00 UTC (exclusive): 3 mentions; 0 submissions, 3 comments2021-10-01 00:00:00 UTC to 2021-11-01 00:00:00 UTC (exclusive): 0 mentions; 0 submissions, 0 comments2021-11-01 00:00:00 UTC to 2021-12-01 00:00:00 UTC (exclusive): 0 mentions; 0 submissions, 0 comments2021-12-01 00:00:00 UTC to 2022-01-01 00:00:00 UTC (exclusive): 0 mentions; 0 submissions, 0 comments2022-01-01 00:00:00 UTC to 2022-02-01 00:00:00 UTC (exclusive): 2 mentions; 0 submissions, 2 commentsJan 20222022-02-01 00:00:00 UTC to 2022-03-01 00:00:00 UTC (exclusive): 0 mentions; 0 submissions, 0 comments2022-03-01 00:00:00 UTC to 2022-04-01 00:00:00 UTC (exclusive): 0 mentions; 0 submissions, 0 comments2022-04-01 00:00:00 UTC to 2022-05-01 00:00:00 UTC (exclusive): 0 mentions; 0 submissions, 0 comments2022-05-01 00:00:00 UTC to 2022-06-01 00:00:00 UTC (exclusive): 0 mentions; 0 submissions, 0 comments2022-06-01 00:00:00 UTC to 2022-07-01 00:00:00 UTC (exclusive): 0 mentions; 0 submissions, 0 comments2022-07-01 00:00:00 UTC to 2022-08-01 00:00:00 UTC (exclusive): 0 mentions; 0 submissions, 0 comments2022-08-01 00:00:00 UTC to 2022-09-01 00:00:00 UTC (exclusive): 2 mentions; 0 submissions, 2 comments2022-09-01 00:00:00 UTC to 2022-10-01 00:00:00 UTC (exclusive): 3 mentions; 0 submissions, 3 comments2022-10-01 00:00:00 UTC to 2022-11-01 00:00:00 UTC (exclusive): 0 mentions; 0 submissions, 0 comments2022-11-01 00:00:00 UTC to 2022-12-01 00:00:00 UTC (exclusive): 1 mentions; 0 submissions, 1 comments2022-12-01 00:00:00 UTC to 2023-01-01 00:00:00 UTC (exclusive): 0 mentions; 0 submissions, 0 comments2023-01-01 00:00:00 UTC to 2023-02-01 00:00:00 UTC (exclusive): 0 mentions; 0 submissions, 0 comments2023-02-01 00:00:00 UTC to 2023-03-01 00:00:00 UTC (exclusive): 1 mentions; 0 submissions, 1 comments2023-03-01 00:00:00 UTC to 2023-04-01 00:00:00 UTC (exclusive): 0 mentions; 0 submissions, 0 comments2023-04-01 00:00:00 UTC to 2023-05-01 00:00:00 UTC (exclusive): 2 mentions; 0 submissions, 2 commentsApr 2023

Counts come from the repository’s dated source evidence. Index cutoff: 2026-11-02 08:16:59 UTC.

View mention counts and date ranges
UTC ranges include their start and exclude their end. Select a period to filter the source evidence.
PeriodStart (UTC)End (exclusive, UTC)MentionsSubmissionsComments
Oct 20202020-10-01 00:00:00 UTC2020-11-01 00:00:00 UTC101
Nov 20202020-11-01 00:00:00 UTC2020-12-01 00:00:00 UTC000
Dec 20202020-12-01 00:00:00 UTC2021-01-01 00:00:00 UTC000
Jan 20212021-01-01 00:00:00 UTC2021-02-01 00:00:00 UTC101
Feb 20212021-02-01 00:00:00 UTC2021-03-01 00:00:00 UTC000
Mar 20212021-03-01 00:00:00 UTC2021-04-01 00:00:00 UTC000
Apr 20212021-04-01 00:00:00 UTC2021-05-01 00:00:00 UTC000
May 20212021-05-01 00:00:00 UTC2021-06-01 00:00:00 UTC000
Jun 20212021-06-01 00:00:00 UTC2021-07-01 00:00:00 UTC101
Jul 20212021-07-01 00:00:00 UTC2021-08-01 00:00:00 UTC000
Aug 20212021-08-01 00:00:00 UTC2021-09-01 00:00:00 UTC000
Sep 20212021-09-01 00:00:00 UTC2021-10-01 00:00:00 UTC303
Oct 20212021-10-01 00:00:00 UTC2021-11-01 00:00:00 UTC000
Nov 20212021-11-01 00:00:00 UTC2021-12-01 00:00:00 UTC000
Dec 20212021-12-01 00:00:00 UTC2022-01-01 00:00:00 UTC000
Jan 20222022-01-01 00:00:00 UTC2022-02-01 00:00:00 UTC202
Feb 20222022-02-01 00:00:00 UTC2022-03-01 00:00:00 UTC000
Mar 20222022-03-01 00:00:00 UTC2022-04-01 00:00:00 UTC000
Apr 20222022-04-01 00:00:00 UTC2022-05-01 00:00:00 UTC000
May 20222022-05-01 00:00:00 UTC2022-06-01 00:00:00 UTC000
Jun 20222022-06-01 00:00:00 UTC2022-07-01 00:00:00 UTC000
Jul 20222022-07-01 00:00:00 UTC2022-08-01 00:00:00 UTC000
Aug 20222022-08-01 00:00:00 UTC2022-09-01 00:00:00 UTC202
Sep 20222022-09-01 00:00:00 UTC2022-10-01 00:00:00 UTC303
Oct 20222022-10-01 00:00:00 UTC2022-11-01 00:00:00 UTC000
Nov 20222022-11-01 00:00:00 UTC2022-12-01 00:00:00 UTC101
Dec 20222022-12-01 00:00:00 UTC2023-01-01 00:00:00 UTC000
Jan 20232023-01-01 00:00:00 UTC2023-02-01 00:00:00 UTC000
Feb 20232023-02-01 00:00:00 UTC2023-03-01 00:00:00 UTC101
Mar 20232023-03-01 00:00:00 UTC2023-04-01 00:00:00 UTC000
Apr 20232023-04-01 00:00:00 UTC2023-05-01 00:00:00 UTC202

What Hacker News says

17 sources
I'm thrilled to see my project (https://mockoon.com) being part of this first cohort! It's a great opportunity but it's also good for open-source projects in general. It can only contribute to make our industry more sustainable. Here is the list of the 20 projects that have been selected: - https://github.com/analogjs/analog: Analog is a fullstack meta-framework to build applications and websites with Angular - https://github.com/Atri-Labs/atrilabs-engine: The Python web framework to build production-grade apps - https://github.com/bigskysoftware/htmx: Makes AJAX, Web Sockets, etc. available directly in HTML - https://github.com/code-hike/codehike: Tools for building all types of code walkthroughs: blogs, docs, slides, tutorials, etc. - https://github.com/DioxusLabs/dioxus: Friendly React-like GUI library for desktop, web, mobile, and mor
Read the rest
e, written in Rust. - https://github.com/EddieHubCommunity/LinkFree: Connecting with your audience with a single link, showcasing your content and projects. - https://github.com/FashionFreedom/Seamly2D: Design CAD to democratize and de-centralize fashion design & production. - https://github.com/fastai/nbdev: Increase developer productivity by 10x with a new exploratory programming workflow. - https://github.com/formbricks/formbricks: Open-source Qualtrics alternative - https://github.com/GyulyVGC/sniffnet: Cross-platform application to comfortably monitor and analyse network traffic - https://github.com/JessicaTegner/pypandoc: Pypandoc provides a thin wrapper for pandoc, a universal document converter. - https://github.com/mockoon/mockoon: Mockoon is the easiest and quickest way to design and run mock REST APIs. - https://github.com/nuxt/nuxt: An intuitive framework for building web applications, built for the edge. - https://github.com/responsively-org/responsively-app: A dev-tool for web developers that aid in faster responsive web page development. - https://github.com/simonw/datasette: An open source multi-tool for exploring and publishing data - https://github.com/spyder-ide/spyder: The scientific Python development environment - https://github.com/strawberry-graphql/strawberry: A GraphQL library for Python that leverages type annotations - https://github.com/termux/termux-app: A terminal emulator for Android that provides 2000+ linux packages to code on phone - https://github.com/TimothyStiles/poly: Poly is a fast, well tested Go package for engineering organisms. - https://github.com/trpc/trpc: End-to-end typesafe APIs made easy. Never write another API contract again. Edit: formatting and updated repo links
In GitHub Accelerator: our first cohort and what’s next
1. Formbricks: Open-source Qualtrics - https://formbricks.com 2. Analog: Fullstack meta-framework for Angular applications - https://analogjs.org/ 3. Atri-Labs Engine: TeamStack for faster Progressive Web Apps development - https://atrilabs.com/ 4. HTMX: AJAX & Web Sockets directly in HTML - https://htmx.org/ 5. Code Hike: Build code walkthroughs for blogs, docs, slides & tutorials - https://codehike.org/ 6. Dioxus: React-like GUI library for multiple platforms, built with Rust - https://dioxuslabs.com/ 7. LinkFree: Connect with your audience through a single link - https://linkfree.io/ 8. Seamly2D: Democratizing fashion design & production with Design CAD - https://github.com/FashionFreedom/Seamly2D 9. Nbdev: Boost developer productivity with an exploratory programming workflow - https://nbdev.fast.ai/ 10. Sniffnet: Cross-platform networ
Read the rest
k traffic monitoring & analysis - https://github.com/GyulyVGC/sniffnet 11. Pypandoc: Thin wrapper for the universal document converter, Pandoc - https://pypi.org/project/pypandoc/ 12. Mockoon: Design and run mock REST APIs with ease - https://mockoon.com/ 13. Nuxt Framework: Intuitive framework for building web applications on the edge - https://nuxt.com/ 14. Responsively App: Accelerate responsive web page development - https://responsively.app/ 15. Datasette: Explore and publish data with this open-source multi-tool - https://datasette.io/ 16. Spyder: Scientific Python development environment - https://www.spyder-ide.org/ 17. Strawberry: Python GraphQL library leveraging type annotations - https://strawberry.rocks/ 18. Termux App: Terminal emulator for Android with 2000+ Linux packages - https://github.com/termux/termux-app 19. Poly: Fast Go package for engineering organisms - https://github.com/TimothyStiles/poly 20. tRPC: End-to-end typesafe APIs made easy - https://trpc.io/
In The Startups in first batch of GitHub OS Accelerator
You might want to look at computational biology. Jim Allison won the Nobel Prize back in 2018 for his work on immunotherapy for cancer and there's a lot of basic research work to be done to perfect this approach. Epigenetic clocks are really interesting too (see Steve Horvath's work). Also, there's synthetic biology, where you could, for example, explore this package that's written in Go: https://github.com/TimothyStiles/poly
In Ask HN: Burnt out from big tech. What's next?
I write synthetic biology software for a living and maintain this open source, Go package for engineering DNA that has high test coverage and a nice little dev community around it. https://github.com/TimothyStiles/poly A large part of my project's community are devs that want to get into the field but can't tolerate the ridiculously low pay, laughably bad management, disrespect, and what amounts to 40+ years of technical debt that's endemic to biotech software. I've had companies here in the Bay Area offer me 100K a year with a straight face. I've had companies during interview tell me they're looking for someone to help, "set up GitHub". I've seen job listings for low paid web dev positions require applicants to have PhDs. The reality is that except for a growing handful of places management straight up won't know the difference between
Read the rest
IT and software engineers. It's what I call the naive buyers problem. The demand for software engineers in biotech is generated by naive buyers that don't know what they need, why they need it, or how to get it. Benchling and Recursion Pharmaceuticals have reputations in the industry of paying, "standard software salaries". So do the research divisions at places like deepmind/microsoft/google but in my experience there's even new multi-billion dollar institutes where senior management has never even heard the term devops. Most places advertise for "data scientist", positions or some analog, instead of software engineers. This is mostly because upper management has never met an actual practicing software engineer in a professional setting. Many come from academia where the culture and work requirements heavily disincentivize standard software engineering practices. It's also not uncommon for a biotech company to either have a very under qualified CTO whose main programming experience is what they learned doing ML research like stuff during their PhD or not even have one at all which has huge downstream consequences. This week a software engineer trying to make the switch to biotech actually DM'd me to ask why they were seeing a ton of data science / ML job positions but no software engineering / devops positions. They were worried that these companies were trying to save on costs by forcing their data scientists to create infrastructure but it's actually worse than that. Most of these companies aren't even aware that there's supposed to be infrastructure. Despite all of this the future is looking better and I'm starting to find new companies and positions that are well... reasonable. I learned about this thread from a friend at a party last night that works at one of these companies. There's a small, strong new wave of companies and developers out there pushing biotech software forward. Hopefully some (including myself) make it big while pushing the idea that better tech equals better biotech.
In Consider working on genomics
Been building in this space for a while - built this with a friend of mine - https://github.com/timothystiles/poly Most of the python packages are honestly... kind of terrible to maintain. Sure, it is easy to whip up a python script to answer your computational question, but maintaining that is extremely hard - as evidenced by the shear number of abandoned python programs written by graduate students that can no longer be run. I used to care about building things quickly, but now I just care about maintenance of things. Maintenance in computational biology is awful right now.
In Open Source Tools for Computational Biology
Could you leave us a git issue on terminology you don't understand? We've tried to make the documentation in the code to make it clearer to non-biologists what is going on (for example, https://github.com/TimothyStiles/poly/blob/prime/seqhash/seq...), but we're honestly too deep to really understand what is not known and how to explain nicely what is going on. If you could help us with asking naive questions that'd help us write a nice primer (which is very useful, since we'd like to recruit more software engineers rather than biologists).
In Ask HN: Who wants to collaborate?
I have experience in DIY genetic engineering (have run a DIY home genetic engineering lab for almost 10 years now https://www.nytimes.com/2018/05/14/science/biohackers-gene-e... ) What you can do and what you can do are different things. Genetic engineering and biological manipulation go as deep as software, and tacit knowledge about execution is non-trivial to the point where you WILL mess up experiments (so expect to repeat a lot). That said, you can still do some fun stuff. I would recommend trying to do something very small but actually novel. For example, if you've done a GFP transformation into E.coli, try to get the GFP transformation working in a new organism (maybe a yogurt bacteria). Keep it small though, and keep it single cellular, or else you are putting yourself into the pit of despair. Also check out the Poly project (https
Read the rest
://github.com/TimothyStiles/poly). We're basically building (decent) open-source software for doing synthetic biology. Since you're a software developer, doing code reviews and reading our mega-comments (like https://github.com/TimothyStiles/poly/blob/prime/transformat...) might help you understand some more of the fundamental engineering problems we synthetic biologists are encountering. Also, in code reviews, if you don't understand something, a practicing synthetic biologist will explain it to you so that we can improve our docs.
In Ask HN: What's an interesting DIY genetic engineering project?

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