Singeli

The kind of things you can use direct SIMD for is a reasonably-different space than array languages; while some things can translate reasonably, APL-likes get much less pretty on operations where elements don't have homogeneous meaning/mapping, e.g.: the base64 conversion of OP. (for reference, I work on https://github.com/dzaima/CBQN, an implementation of BQN, an APL derivative, and we have a DSL for implementing SIMD primitives for it (and sometimes scalar ones too): https://github.com/mlochbaum/Singeli)

I did this! Singeli is an Elixir-like compile-time language where types and variables are first-class values, on top of C-ish semantics that are meant to be more like "portable assembly". It's designed for high-performance code where you have to be able to control the specific instructions, but the overall strategy could be useful in other domains too. https://github.com/mlochbaum/Singeli And a podcast on it came out Friday: https://www.arraycast.com/episodes/episode62-what-is-singeli

By "large" I mean compared to the fraction of needs-slow-emulation things present currently in C (which is currently approximately zero, other than using integer/float types unsupported on the target hardware (and maybe multiplication/division), but that's comparatively extremely easy to determine). Maybe my use-case - implementing an array language - is unusually unfit for being done in a generic way, but I just don't see how it (or much of anything outside of very trivial things) would be reasonable to figure out how to do performantly with anything other than either manually using intrinsics, or with custom-written abstractions around such with known worst-case emulation amount (we're doing[0] the latter with a DSL[1] that's basically a basic compile-time code generator; that just leaves unsupported things undefined on any given archit